abstract：:The localization of the beta/A4 amyloid precursor protein (APP) was studied in the human lumbar paravertebral sympathetic ganglia of subjects of different ages, free of neurologic disease, using combined immunohistochemistry and image analysis techniques (optic microdensitometry). To ascertain which cells displayed AP...

journal_title：Mechanisms of ageing and development

authors： Calzada B,Cabal A,Naves FJ,del Valle ME,Represa JJ,Vega JA

更新日期：1994-10-20 00:00:00

abstract：:The present report analyzes the suppressor cell system of aged rats in an experimental model of autoimmunity to rat male accessory glands (RAG). A state of specific suppression to RAG was induced when young rats are pretreated with peritoneal cells (PC) obtained from syngeneic young rats i.p. injected 2 h previously w...

journal_title：Mechanisms of ageing and development

authors： Pistoresi-Palencia MC,Romero-Piffiguer M,Morón G,Ferro ME

更新日期：1994-10-01 00:00:00

abstract：:T cell activation involves events at the plasma membrane; therefore, molecules such as long chain omega-3 fatty acids that alter the structure of the plasma membrane may affect the activation of aged T cells. In this project we investigated whether the incorporation of omega-3 fatty acids (from fish oil), in the prese...

journal_title：Mechanisms of ageing and development

authors： VanMeter AR,Ehringer WD,Stillwell W,Blumenthal EJ,Jenski LJ

更新日期：1994-08-01 00:00:00

abstract：:The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidat...

journal_title：Mechanisms of ageing and development

authors： Agarwal S,Sohal RS

更新日期：1994-07-01 00:00:00

abstract：:delta-Aminolevulinic acid synthase and heme oxygenase are closely functionally connected with the hepatic microsomal mixed function oxydase system. There is a wide range of changes in microsomal heme oxygenase activity, cytochrome P-450 level and mitochondrial delta-aminolevulinic acid synthase activity in rat livers ...

journal_title：Mechanisms of ageing and development

authors： Plewka A,Bienioszek M,Plewka D

更新日期：1994-05-01 00:00:00

abstract：:Several alternative mortality models fit Swedish old-age mortality data equally well. The models build on two different concepts of the heterogeneity of individuals in a population. The first concept concerns fixed, genetic differences among individuals in their risk of death. The second concept involves acquired susc...

journal_title：Mechanisms of ageing and development

authors： Yashin AI,Vaupel JW,Iachine IA

更新日期：1994-05-01 00:00:00

abstract：:Lipid peroxidation, one of the most common expressions of oxidative stress, may be altered during normal physiological states including development. We have examined the changes in lipid peroxidation in rat brain, a tissue highly susceptible to oxidative damage, during this physiological state. In vivo lipid peroxidat...

journal_title：Mechanisms of ageing and development

authors： Pushpendran CK,Subramanian M,Devasagayam TP

更新日期：1994-03-01 00:00:00

abstract：:The present study was designed to assess whether treatment with the monoamine oxidase-B (MAO-B) inhibitor L-deprenyl, which has been documented to increase both mean and maximum survival in aged rats as well as sexual performance and cognitive function, has any effect on the age-related microanatomical changes occurri...

journal_title：Mechanisms of ageing and development

authors： Zeng YC,Bongrani S,Bronzetti E,Cadel S,Ricci A,Valsecchi B,Amenta F

更新日期：1994-02-01 00:00:00

abstract：:Lipofuscin-specific autofluorescence of living, cultured rat neonatal myocardial myocytes was studied with respect to intensity and spectral characteristics. The autofluorescence emission spectrum changed over time indicating continuously ongoing intramolecular reorganisation of the pigment. Moreover, as compared with...

journal_title：Mechanisms of ageing and development

authors： Gao G,Johansson U,Rundquist I,Ollinger K

更新日期：1994-01-01 00:00:00

abstract：:The most relevant theories on the sex-dependent longevity at population level are critically re-examined in the light of the knowledge available today on the aging process at cellular and molecular level. The aim of this perspective is to help in the understanding of the cellular and molecular bases of longevity and t...

journal_title：Mechanisms of ageing and development

authors： Magnani M,Accorsi A

更新日期：1993-12-15 00:00:00

abstract：:The strychnine-insensitive binding of [3H]glycine was characterized in purified cerebral cortical membranes from mice aged from 7 days to 22 months. The binding was saturable, exhibiting only one component during the whole life-span studied. The binding constant KD did not change during development and ageing, whereas...

journal_title：Mechanisms of ageing and development

authors： Saransaari P,Oja SS

更新日期：1993-11-01 00:00:00

abstract：:The purpose of this study was to determine the feasibility of using a recently developed procedure, dual-energy x-ray absorptiometry, to determine body composition in rats as a function of aging. Results were obtained that were consistent with previous findings for male rats. ...

journal_title：Mechanisms of ageing and development

authors： Rikans LE,Venkataraman PS,Cai Y

更新日期：1993-10-01 00:00:00

abstract：:A comprehensive study on GSH metabolism in relation to some markers of oxidative and energy status in rat cerebral cortex as a function of age was performed. Reduced GSH, total GSH and the GSH Redox Index decreased both during growth (defined as the period between 1 and 5 months) and during aging (defined as the perio...

journal_title：Mechanisms of ageing and development

authors： Iantomasi T,Favilli F,Marraccini P,Stio M,Treves C,Quattrone A,Capaccioli S,Vincenzini MT,Quatrone A corrected to Quattrone A

更新日期：1993-08-01 00:00:00

abstract：:Elderly people are at risk from an increased incidence of infections. Therefore we have studied the correlation between the production of several immunological parameters such as interferon-gamma (IFN-gamma), interferon-alpha-2 (IFN-alpha-2), interleukin-2 (IL-2), soluble interleukin-2 receptors (sIL-2R) and interleuk...

journal_title：Mechanisms of ageing and development

authors： Sindermann J,Kruse A,Frercks HJ,Schütz RM,Kirchner H

更新日期：1993-08-01 00:00:00

abstract：:In order to determine whether the function of alveolar macrophages (AM) is modulated by aging, we measured the TNF-alpha production, phagocytic function, and surface antigen expression of AM from young and old mice. When AM were primed by IFN-gamma (500 units/ml) and triggered by LPS (100 micrograms/ml), TNF-alpha pro...

journal_title：Mechanisms of ageing and development

authors： Higashimoto Y,Fukuchi Y,Shimada Y,Ishida K,Ohata M,Furuse T,Shu C,Teramoto S,Matsuse T,Sudo E

更新日期：1993-07-01 00:00:00

abstract：:Published data on age-related human biological functions are surveyed. For the many showing a linear decrease, regressions were calculated, or existing functions extrapolated, to yield an intercept on the abscissa. The values of chi(0), the age at which a function ceases, provide a tentative common means of comparison...

journal_title：Mechanisms of ageing and development

authors： Weale RA

更新日期：1993-06-01 00:00:00

abstract：:Age related changes in some aspects of glutamate metabolism were followed in the brain of a short lived species of tropical murrel, Channa punctatus. Both ammonia and glutamine contents of brain increased with advancing age of the murrel. The glutamate dehydrogenase activity of brain increased during maturation phase ...

journal_title：Mechanisms of ageing and development

authors： Mahapatro N,Patnaik BK

更新日期：1993-05-01 00:00:00

abstract：:Great importance is attached to structural and functional deterioration of mitochondria as a reason for ageing of an organism; the attention of many scientists has been concentrated on such questions as age changes in the system of oxidative phosphorylation, damage of mitochondrial DNA by free radicals generated in th...

journal_title：Mechanisms of ageing and development

authors： Lemeshko VV,Shekh VE

更新日期：1993-05-01 00:00:00

abstract：:A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...

journal_title：Mechanisms of ageing and development

authors： Ishi N,Suzuki N,Hartman PS,Suzuki K

更新日期：1993-05-01 00:00:00

abstract：:We examined the effects of voluntary exercise on glucose transporter concentration in skeletal muscle from young adult and old female Long-Evans rats. Rats had free access to voluntary running wheels beginning at 4 months of age or remained sedentary. Exercising rats ran approximately 7.5, 6.2, 5.6 and 5.3 km/day duri...

journal_title：Mechanisms of ageing and development

authors： Gulve EA,Rodnick KJ,Henriksen EJ,Holloszy JO

更新日期：1993-02-01 00:00:00

abstract：:Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genet...

journal_title：Mechanisms of ageing and development

authors： Thakur MK,Oka T,Natori Y

更新日期：1993-01-01 00:00:00

abstract：:Formalinized Mycoplasma pulmonis was used to immunize 3 different age groups of Fischer 344 rats. A specific antibody to this antigen was detected in both saliva and lung lavage fluids and differences were noted in the elicitation of secretory antibody between the different ages of the animals. Few statistical differe...

journal_title：Mechanisms of ageing and development

authors： Steffen MJ,Ebersole JL

更新日期：1992-11-01 00:00:00

abstract：:To investigate age-related changes in gene expression in WI-38 cells, we isolated RNA from young and senescent, quiescent cultures and made subtracted cDNA libraries. Density-arrested cells were incubated in serum-free MCDB-104 for 3 days. RNA was then isolated and subtracted cDNA libraries were made in the phagemid v...

journal_title：Mechanisms of ageing and development

authors： Doggett DL,Rotenberg MO,Pignolo RJ,Phillips PD,Cristofalo VJ

更新日期：1992-09-01 00:00:00

abstract：:Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. H...

journal_title：Mechanisms of ageing and development

authors： Riggs JE,Millecchia RJ

更新日期：1992-09-01 00:00:00

abstract：:It has been previously well documented that partial pressure of oxygen (PO2) and weight-specific rate of O2 consumption in chick embryo (Gallus gallus domesticus) transiently increase midway through the 21-day in ovo incubation period. The present study found that these oxidative changes were paralleled by the concent...

journal_title：Mechanisms of ageing and development

authors： Wilson JX,Lui EM,Del Maestro RF

更新日期：1992-08-01 00:00:00

abstract：:To explore whether catecholaminergic lesions produced chemically in the nucleus tractus solitarius (NTS) would alter the baroreflex impairment that normally occurs with age, we compared baroreflex responses in 3- and 14-month-old rats given bilateral microinjections of 6-hydroxydopamine (6-OHDA) or its vehicle into th...

journal_title：Mechanisms of ageing and development

authors： Itoh H,Buñag RD

更新日期：1992-06-01 00:00:00

abstract：:Impaired lymphocyte and granulocyte function in the aged may, in part, reflect intrinsic aged-related biochemical alterations. In this study we compared the ribonucleotide contents of lymphocytes and granulocytes from young and old subjects evaluated by means of an HPLC-anion exchange method. We found that in general ...

journal_title：Mechanisms of ageing and development

authors： Borzì RM,Dal Monte P,Uguccioni M,Meliconi R,Facchini A

更新日期：1992-06-01 00:00:00

abstract：:Age-related changes in regulation of receptor response have been observed in several tissues and include regulation of beta-adrenergic receptor (beta-receptor) responses. The role of cellular aging in age-related changes in receptor response is not clear. We have examined the effect of aging in vitro on human fibrobla...

journal_title：Mechanisms of ageing and development

authors： Kilfeather SA,Collins D,McCormack P,Cotter T,O'Malley K

更新日期：1992-05-01 00:00:00

abstract：:The effects of ageing and of exercise on muscle mass, fiber cross-sectional area, and fiber type composition of a weight-bearing muscle, the soleus and a non-weight-bearing muscle, the extensor digitorum longus (EDL) were investigated in female Long-Evans rats. The animals were exercised by means of voluntary wheel ru...

journal_title：Mechanisms of ageing and development

authors： Brown M,Ross TP,Holloszy JO

更新日期：1992-03-15 00:00:00

abstract：:We compared cardiovascular responses to various adrenergic agonists in conscious 3-month and 12-month old rats that had been treated with propranolol daily for 7 days, to determine whether changes in beta-adrenergic hypersensitivity induced by abrupt propranolol withdrawal would differ with age. Depressor and tachycar...

journal_title：Mechanisms of ageing and development

authors： Teräväinen TL,Buñag RD

更新日期：1992-03-15 00:00:00

abstract：:Aqueous solutions of zirconium oxychloride were added to human peripheral blood lymphocyte culture. Cultures were set up from healthy donors of both sexes belonging to age groups of 0-10, 11-20, 21-30, 31-40, 41-50 and 51-60 years. Airdried Giemsa schedule was followed for preparation of chromosomal aberrations and mi...

journal_title：Mechanisms of ageing and development

authors： Ghosh S,Talukder G,Sharma A

更新日期：1992-03-01 00:00:00

abstract：:The age-related changes of the ciliary muscle of human eyes (33-87 years) were studied on histological meridional sections. Eighty-five melanoma eyes and 10 eyes of normal donors were investigated. The total area and the length of the muscle, the area of the three main portions and the distance of the inner apex of th...

journal_title：Mechanisms of ageing and development

authors： Tamm S,Tamm E,Rohen JW

更新日期：1992-02-01 00:00:00

abstract：:The antigen-specific antibody secretion in vitro after immunisation with the primary T-cell dependent antigen Helix pomatia Haemocyanin (HPH) was investigated in both young and elderly individuals, who all met the health admission criteria for immunogerontological studies as detailed in the SENIEUR protocol. In additi...

journal_title：Mechanisms of ageing and development

authors： De Greef GE,Van Staalduinen GJ,Van Doorninck H,Van Tol MJ,Hijmans W

更新日期：1992-01-01 00:00:00

abstract：:The in vitro replicative potential of human diploid fibroblasts can be increased by polypeptide growth factors such as epidermal growth factor (EGF). Also, the cycle time of EGF-stimulated cells is, on average, decreased and their mitotic cell volume is reduced. Therefore, the regulation of cell size by the duration o...

journal_title：Mechanisms of ageing and development

authors： Angello JC

更新日期：1992-01-01 00:00:00

abstract：:We showed earlier that life spans of murine B lymphocytes could be estimated by measuring the functional reactivities of normal B cells upon transfer into x-linked immunodeficient (xid) mice, which do not respond to anti-mouse IgM (anti-mu) antibodies and thymic-independent type-2 (TI-2) antigens. Here the same approa...

journal_title：Mechanisms of ageing and development

authors： Udhayakumar V,Goud SN,Cross RJ,Subbarao B

更新日期：1991-12-02 00:00:00

abstract：:The effects of age and chronic propranolol treatment on the agonist-induced rise in intracellular free Ca2+ ([Ca2+]i), an index for the coupling of receptor-second messenger generation, was studied using a dispersed rat submandibular gland preparation. Muscarinic stimulation (10 microns carbachol) caused a rapid (T1/2...

journal_title：Mechanisms of ageing and development

authors： Melvin JE,O'Connell AC,Koek L,Bowen WH

更新日期：1991-11-15 00:00:00

abstract：:The microtubule-associated protein tau, and the cytoplasmic protein ubiquitin, are constituents of pathological neurofibrillary tangles found in Alzheimer's disease. In order to see if there is any physiological relationship between these proteins in a functioning human system, human neuroblastoma (LAN-5) cells were g...

journal_title：Mechanisms of ageing and development

authors： Mesco ER,Timiras PS

更新日期：1991-11-15 00:00:00

abstract：:During experiments on the molecular basis of morphological and functional changes observed in rat liver mitochondria upon aging, we found that the buoyant density profile of mitochondrial DNA (mtDNA) shows a wide distribution pattern especially in the lighter region than that of young rat liver mtDNA. The heterogeneou...

journal_title：Mechanisms of ageing and development

authors： Asano K,Amagase S,Matsuura ET,Yamagishi H

更新日期：1991-11-01 00:00:00

abstract：:Age-adjusted mortality rates for breast cancer (BC) in the United States from 1962 to 1987 were subjected to longitudinal Gompertzian analysis. Age-adjusted BC mortality rate distributions for women display two distinct Gompertzian slopes. Between age 15 and 40 years, age-adjusted BC mortality rate distributions inter...

journal_title：Mechanisms of ageing and development

authors： Riggs JE

更新日期：1991-10-01 00:00:00

abstract：:Twenty-six institutionalized elderly subjects, selected as healthy according to the SENIEUR protocol, were compared to adult controls to establish correlations between affective disorders and immune abnormalities and to investigate underlying neuroendocrine mechanisms. After an extensive psychodiagnostic examination, ...

journal_title：Mechanisms of ageing and development

authors： Bartoloni C,Guidi L,Frasca D,Antico L,Pili R,Cursi F,Di Giovanni A,Rumi C,Menini E,Carbonin P

更新日期：1991-09-01 00:00:00